Abstract
Cancer metastasis is a complex and multi-step process that involves the spread of cancer cells from a primary tumor to distant organs. The genetic mechanisms driving metastasis are not fully understood, but recent advances in genomics and molecular biology have provided valuable insights into this process. This article explores the genetic alterations that contribute to cancer metastasis, including mutations, gene expression changes, and epigenetic modifications. It discusses key genes and signaling pathways involved in metastasis, such as the epithelial-to-mesenchymal transition (EMT), the role of tumor microenvironment, and the contribution of circulating tumor cells (CTCs). Additionally, the article highlights current research on metastasis-targeted therapies and the challenges associated with preventing or treating metastatic cancer.
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