The Role of Gelsolin in Cell Motility and Cancer Progression

Abstract

Gelsolin is an actin-binding protein that plays a critical role in the regulation of cell motility and shape by severing actin filaments and capping their ends. This article explores the multifaceted role of gelsolin in regulating cellular dynamics, particularly in the context of cancer progression. We discuss the molecular mechanisms by which gelsolin modulates cell motility, its involvement in processes such as metastasis and tumor invasion, and its potential as a therapeutic target in cancer treatment. Furthermore, we review the role of gelsolin in actin dynamics and its implications for cancer cell migration and adhesion.