The Role of Chromatin Remodeling in Gene Expression

Abstract

Chromatin remodeling is a dynamic process that regulates gene expression by modifying the structure of chromatin, making it more or less accessible to transcription factors and other regulatory proteins. This article explores the molecular mechanisms underlying chromatin remodeling and its role in the regulation of gene expression. We discuss the different classes of chromatin remodeling complexes, their enzymatic activities, and how they interact with histone modifications and DNA methylation. Additionally, we examine the impact of chromatin remodeling on various cellular processes, including development, differentiation, and disease, particularly cancer. Finally, we review the potential therapeutic applications of chromatin remodeling in the treatment of gene expression-related diseases.