Understanding the Role of Cell Cycle Regulation in Cancer

Abstract

The regulation of the cell cycle is critical for maintaining cellular homeostasis and preventing uncontrolled cell proliferation. Dysregulation of the cell cycle is a hallmark of cancer, leading to unchecked cell division and tumor formation. This article explores the molecular mechanisms that control the cell cycle and how their disruption contributes to the development of cancer. We discuss the roles of cyclins, cyclin-dependent kinases (CDKs), checkpoint proteins, and tumor suppressors in regulating cell cycle progression. Furthermore, we examine how mutations in these regulatory pathways promote cancer and explore potential therapeutic strategies aimed at restoring normal cell cycle control in cancer cells.