Abstract
The blood-brain barrier (BBB) is a selective permeability barrier that protects the brain from potentially harmful substances while allowing essential nutrients to pass through. However, the BBB also presents a significant challenge in the delivery of therapeutic agents to treat neurological disorders. Drug delivery systems (DDS) have been developed to overcome the BBB, enabling the targeted delivery of drugs to the brain. This article discusses the different strategies used in drug delivery systems, including nanoparticle-based systems, lipid-based carriers, and focused ultrasound, to enhance drug transport across the BBB. We also examine the challenges, opportunities, and future directions for improving drug delivery to the brain.
All articles published in the American Journal of Pharmacy and Pharmacology are licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). This license allows others to:
-
Share — copy and redistribute the material in any medium or format
-
Adapt — remix, transform, and build upon the material for any purpose, even commercially
Under the following terms:
-
Attribution — Appropriate credit must be given to the original author(s) and source, a link to the license must be provided, and any changes made must be indicated.
By submitting their work, authors agree to these licensing terms and retain copyright of their articles.