Abstract
The gut microbiota plays a pivotal role in drug metabolism, influencing the pharmacokinetics and pharmacodynamics of various therapeutic agents. Microbial enzymes can activate, deactivate, or transform drugs, impacting efficacy and toxicity. Recent studies highlight the significance of the gut microbiome in modulating individual responses to medications. This article reviews current knowledge on the interactions between gut microbiota and drugs, the implications for personalized medicine, and future directions in microbiome-targeted pharmacology.
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