Abstract
Human infectious diseases, caused by bacteria, viruses, fungi, and parasites, remain a major global health concern. Bioinformatics has become an essential tool in investigating the molecular mechanisms underlying infectious diseases, from pathogen genomics to host-pathogen interactions. Advancements in high-throughput sequencing technologies, metagenomics, and systems biology have enabled comprehensive studies of infectious diseases at the genomic and transcriptomic levels. This article explores the role of bioinformatics in investigating human infectious diseases, focusing on pathogen identification, virulence factor prediction, host immune response analysis, and the development of diagnostics and therapeutic strategies. We also discuss the challenges and future directions of using bioinformatics in the study of infectious diseases.
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